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Ginseng extract and ginsenosides improve neurological function and promote antioxidant effects in rats with spinal cord injury: A meta-analysis and systematic review

Journal of Ginseng Research 2022년 46권 1호 p.11 ~ 22
Sng Kim Sia, Li Gan, Zhou Long-Yun, Song Yong-Jia, Chen Xu-Qing, Wang Yong-Jun, Yao Min, Cui Xue-Jun,
소속 상세정보
 ( Sng Kim Sia ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease
 ( Li Gan ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease
 ( Zhou Long-Yun ) - Jiangsu Provincial People’s Hospital Rehabilitation Medicine Center
 ( Song Yong-Jia ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease
 ( Chen Xu-Qing ) - Nanjing University of Chinese Medicine Affiliated Hospital Department of Otolaryngology
 ( Wang Yong-Jun ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease
 ( Yao Min ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease
 ( Cui Xue-Jun ) - Shanghai University of Traditional Chinese Medicine Longhua Hospital Institute of Spine Disease

Abstract


Spinal cord injury (SCI) is defined as damage to the spinal cord that temporarily or permanently changes its function. There is no definite treatment established for neurological complete injury patients. This study investigated the effect of ginseng extract and ginsenosides on neurological recovery and antioxidant efficacies in rat models following SCI and explore the appropriate dosage. Searches were done on PubMed, Embase, and Chinese databases, and animal studies matches the inclusion criteria were selected. Pair-wise meta-analysis and subgroup analysis were performed. Ten studies were included, and the overall methodological qualities were low quality. The result showed ginseng extract and ginsenosides significantly improve neurological function, through the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale (pooled MD = 4.40; 95% CI = 3.92 to 4.88; p < 0.00001), significantly decrease malondialdehyde (MDA) (n = 290; pooled MD = ?2.19; 95% CI = ?3.16 to ?1.22; p < 0.0001) and increase superoxide dismutase (SOD) levels (n = 290; pooled MD = 2.14; 95% CI = 1.45 to 2.83; p < 0.00001). Both low (<25 mg/kg) and high dosage (≥25 mg/kg) showed significant improvement in the motor function recovery in SCI rats. Collectively, this review suggests ginseng extract and ginsenosides has a protective effect on SCI, with good safety and a clear mechanism of action and may be suitable for future clinical trials and applications.

키워드

Ginseng extract; Ginsenosides; Meta-analysis; Spinal cord injury; Systematic review

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