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Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis

Journal of Ginseng Research 2022년 46권 1호 p.126 ~ 137
Yang Da-Ram, 정현의, 황승미, 김종원, 문희원, 이예은, 오효빈, 박충범, 김범석,
소속 상세정보
 ( Yang Da-Ram ) - Chonbuk National University College of Veterinary Medicine
정현의 ( Jeong Hyun-Eui ) - Chonbuk National University College of Veterinary Medicine
황승미 ( Hwang Seung-Mi ) - Institute of Jinan Red Ginseng Department of Efficacy Study
김종원 ( Kim Jong-Won ) - Chonbuk National University College of Veterinary Medicine
문희원 ( Moon Hee-Won ) - Chonbuk National University College of Veterinary Medicine
이예은 ( Lee Ye-Eun ) - Institute of Jinan Red Ginseng Department of Efficacy Study
오효빈 ( Oh Hyo-Bin ) - Institute of Jinan Red Ginseng Department of Efficacy Study
박충범 ( Park Chung-Berm ) - Institute of Jinan Red Ginseng Department of Efficacy Study
김범석 ( Kim Bum-Seok ) - Chonbuk National University College of Veterinary Medicine

Abstract


Background: Nonalcoholic steatohepatitis (NASH) is one of the main chronic liver diseases. NASH is identified by lipid accumulation, inflammation, and fibrosis. Jinan Red Ginseng (JRG) and licorice have been widely used because of their anti-inflammatory and hepatoprotective effects. Hence, this study assessed JRG and licorice extract mixtures' effects on NASH progression.

Methods: Palmitic acid (PA) and the western diet (WD) plus, high glucose-fructose water were used to induce in vitro and in vivo NASH. Mice were orally administered with JRG-single (JRG-S) and JRG-mixtures (JRG-M; JRG-S + licorice) at 0, 50, 100, 200 or 400 mg/kg/day once a day during the last half-period of diet feeding.

Results: JRG-S and JRG-M reduced NASH-related pathologies in WD-fed mice. JRG-S and JRG-M consistently decreased the mRNA level of genes related with inflammation, fibrosis, and lipid metabolism. The treatment of JRG-S and JRG-M also diminished the SREBP-1c protein levels and the p-AMPK/AMPK ratio. The FAS protein levels were decreased by JRG-M treatment both in vivo and in vitro but not JRG-S.

Conclusion: JRG-M effectively reduced lipogenesis by modulating AMPK downstream signaling. Our findings suggest that this mixture can be used as a prophylactic or therapeutic alternative for the remedy of NASH.

키워드

Jinan Red Ginseng; Licorice; Mice; Nonalcoholic steatohepatitis

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