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Flow Cytometry를 이용한 DNA분석과 고형종양의 예후

Prognostic Significance of Flow Cytometric DNA Analysis in Solid Tumors

고신대학교의학부논문집 1992년 8권 2호 p.181 ~ 196
백승언, 선연명, 이승도,
소속 상세정보
백승언 (  ) - 고신대학교 의과대학
선연명 (  ) - 고신대학교 의과대학
이승도 (  ) - 고신대학교 의과대학

Abstract


Flow cytometric DNA content analysis is a rapid, quantitative method of determining the DNA ploidy status and proliferative index of a given tumor. Aneuploidy is present in 60-70% of solid tumors and has been recognized as a marker of
malignancy and unfavorable prognosis.
Also, high S-phase fraction has been recognized as an expression of biological aggressiveness and poor prognosis. This method has been applied widely to many kinds of malignant tumors to evaluate it's prognostic significance and possibility of
clinical application. But the results are still contriversial according to the exminers and kinds of tumors. to evaluate prognostic significance of this method in gastric carcinoma we examined DNA ploidy and survival time of 235 gastric
cancer
patients who underwent opertions at the Departement of Surgery, Kosin Medical College between January 1979 and June 1981, and the results were compared with other prognostic factors such as TNM atage, histologic grade, Lauren's
classification
and patients age along with a collective review of recent literatures.

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