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慢性一酸化炭素中毒에 關한 實驗的硏究

Experimental Studies on the Chronic Carbon-Monoxide Poisoning

공중보건잡지 1965년 2권 1호 p.21 ~ 29
김종석,
소속 상세정보
김종석 (  ) - 서울대학교 의과대학 예방의학교실

Abstract


To observe changes in the hemogram, liver function, tissue oxygen consumption rate & body weight of rats those had been exposed to the 0.05%CO and the 0.1% CO atmosphere for 5 weeks, this study was undertaken following conclusions were observed.
1) Continuous increase of hemoglobin and hematocrit value was observed in the chronic 0.05% and the ch-ronic 0.1% carbon-monoxide exposure group and it was getting prominent at end if 4 weeks exposure up to final 5 weeks.
2) No remarkable changes of Mean Corpuscular Hemoglobin concentration were observed in the chronic 0.05% CO exposure group but slight increase in the chronic 0.1% CO exposure group could be observed.
2) Total plasma protein, albumin and Globulin decreased gradually as the exposure prolongs in both experim-ental group.
3) Icterus index showed no remarkable changes but slight increase in the chronic 0.1% CO exposure group was observed.
4) Tissue oxygen consumption rate increased in the end of 2 & 3 weeks exposure but returned to original value at the end of 4 & 5 weeks exposure.
5) The chronic CO exposure group showed continued body weight loss through the exposure and cessation of the growth in reference to the body weight could be seen.

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