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精路閉塞에 관한 硏究

Studies on Bilateral Obstruction of Seminal Tracts

공중보건잡지 1971년 8권 2호 p.241 ~ 257
전경훈,
소속 상세정보
전경훈 (  ) - 서울대학교 대학원 豫防醫學敎室

Abstract


To investigate the effects of bilateral occlusion of the seminal ducts, biological, histologic, and histochemical studies on vasectomized animals and clinical studies on 35 cases of epididymal obstructions and 99 cases of vasal obstructions were carried out and the results were presented in this report.
Ⅰ. Animal study
1) In biological study, no particular effects by vasectomy could be found according to the changes of body weight, and of the weights of certain organs such as prostate, seminal vesicles, epididymes, andtestes before and after the vasectomy.
2) No significant differences in histologic pictures were found between the control group and vasectomy groups by the spermatogenesis the Sertoli cells, and Leydig cells.
3) In histochemical study, the reactive patterns of the alkaline phosphatase activity staining as an indication of metabolic activity of cells and tissues of testes in the vasectomy groups were similar to thise seen in the control group.
Ⅱ. Clinical study:
1) In coital frequencies, no significant differences were found between epididymal obstruction group and vasal obstruction group by thier occupations. educational levels, and post-recanalization. No definite changes were found in the average volume of pre-and post-operative ejaculates among groups of epididymal obstruction, vasal obstruction, and normal, even though considerable individual diffences were noted among these subjects.
2) Biochemically, the average value of 17-ketosteroid in 24 hours´ urine was 12.7mg in the epididymal obstruction group, and 12.4mg in vasectomy group. It was much the same with the average of normal contro´s of smae age group.
3) The testicular biopsies showed no significant changes between groups of epididymal obstruction and vasal obstruction.
By way of conclusion, these studies in animal and human revealed that the absence of free passage for sperm did not lead to atrophy of the seminiferous tubules, and that the reproductive deficiency did not involve the endocrine component of the testis. In other words, results of thest studies indicated that not only was spermatogenesis not halted by obstruction of the epididymes or vas deferens, but also that hyperplasia of the Leydig cells did not occur.

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