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自然能動免疫과 人工能動免疫의 相關關係

Correlation between natrual Active immunity and Artificial Active Immunity

공중보건잡지 1975년 12권 1호 p.1 ~ 11
노인규,
소속 상세정보
노인규 ( Loh In-Kyu ) - 서울대학교 보건대학원

Abstract


The degree natural active immunity (acquired by natural infection) and artificial active immunity (acquired by immunization) of communicable diseases was reviewed and classified into strong, moderate, weak and negligible immunity, respectively. In fact there are several diseases of which the nature of their natural active immunity is still not well understood and the vaccines for immunization are not yet developed.
For the diseases of which the degree of both the natural and artificial active immunity is well understood , the correlation between natural active immunity and artificial active immunity was observed.
As a result of observation, the findings were that there were no diseases in which the degree of artifical active immunity surpassed that of the natual active immunity and that there was statistically a high significant (p<0.001) correlation (r=0.89) between natural and artificial active immunity as shown in the table and figure.
On the basis of such findings, the hypotheses may be formulated that, vaccines for the communicable diseases might be developed which produce effective immune level as high as those of the natural active immunity of the same diseases and such vaccines producing immune levels, surpassing those of the natural active immunity might not be expected to be developed.1) In case of communicable diseases which have vaccines for producing immunity degree as much as those of their natural active immunity, no further development of vaccine effectiveness may be expected.
2) In communicable diseases which have vaccines for producing immunity degree less than those of their natural active immunity, the vaccines may be developed further to produce immunity degree as much as those of the natural active immunity.
3) In communicable diseases which produce low or negligible degree of natural active immunity, vaccines with satisfactory effectiveness may not be expected to be developed. Therefore in such diseases trials of vaccine development might be meaningless.
4) In communicable diseases which produce strong or moderate degree of natural active immunity but no vaccines have been developed yet, trials of vaccine development may result in satisfactory outcome.
5) In communicable diseases of which the nature of natural active immunity is not well understood yet, the above explanation may also be applicable when the nature of the immunity is thoroughly studied.

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