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內服用 液劑의 最適加熱殺菌條件에 關한 硏究

On the Germicidal Effect of Oral Liquid Medicine by Thermal Processing

공중보건잡지 1976년 13권 1호 p.49 ~ 56
이도홍,
소속 상세정보
이도홍 (  ) - 서울대학교 보건대학원

Abstract


An experimental study was carried out to get optimal conditions of oral liquid medicine by thermal processing.
We made two kinds of samples which contained Thiamine·HNO₃and Niacinamide, added Bacillus subtils quantitiviely, and sterilized by autoclave; the variable conditions were time(min.) and temperature(℉).
The effectes of heating temperature and period on the medicine were as follows:
1. When thermal processing is applied on the oral liquid medicine, optimal condition which can´t degrade drug effect but destroy contaminated microrganism is 250℉ in highest heating temperature and 3 minutes in sterility time.
2. When the medicine containes natural product´s extract, optimal condition is 250℉ in temperature and 5 minutes in time.
3. When thermal processing is being held at 250℉ in temperature and 3 minutes in time, appropriate total sterility time is 30-40 minutes. On this conditions, suitable come-up time is 60%-80% of total sterility time.

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