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우리나라에서 分離한 腸티브스菌에 對한 抗菌劑 感受性 調査硏究

A Study on the Susceptibility Test of Salmonella to the Selective Antimicrobial Agents in Krea, 1975

공중보건잡지 1976년 13권 2호 p.271 ~ 282
송준상,
소속 상세정보
송준상 (  ) - 서울대학교 보건대학원

Abstract


The antimicrobial susceptibility tests with ampicillin (AM), chloramphenicol (CM), colistin (Co), gentamycin (GM), kanamycin (KM), neomycin (NM), streptomycin (SM), tetracycline and trimethoprim/sulfamethoxazole (TS) were performed to 121 cultures of Salmonella typhi isolated in various parts of Korea during the period from February to December, 1975.
Single disc method and MIC and MCC by the tube dilution method were performed in this experiments and the results obtained were summarized as follows:
1. The distibution of susceptible cultures tested by the single disc method to the various antimicrobial agents were as follows: AM: 92.6%, CM: 99.2%, Co: 76.0%, GM: 99.2%, KM: 99.2%, NM: 96.7%, PG: 44.6%, SM: 61.0%, TM: 37.2%.
2. The distribution of susceptible cultures tested by the MIC method to the various antimicrobial agents were as follows: AM: 85.3%, CM: 93.4%, Co: 91.7%, GM: 94.2%, KM: 85.3%, NM: 100%, PG: 52.9%, SM: 43.8%, TM: 37.2%, TS: 100%.
3. The distribution of the cultures within the range of susceptibility by the determining MCC to subculture to the various antimicrobial agents were as follows: AM: 78.5% CM: 45.5%, Co: 72.7%, GM: 80.2%, KM: 33.9%, NM: 97.5%, PG: 33.1%, SM: 2.5%, TM: 7.4%, TS: 89.3%.
4. The somparison between the Antimicrobial susceptibility tests employing single disc and MIC method were performed and their agreements were as follows: AM: 92.6%, CM: 94.2%, Co: 81.0%, GM: 95.0%, KM: 84.3%, NM: 96.7%, PG: 78.5%, SM: 74.4%, TM: 86.0%.
5. The Bactericidal action of the various antimicrobial agents appeared in following times concentration than MIC.
AM: 1.9 times (SD: 1.30), CM: 3.9 times (SD: 1.33), Co: 2.2 times (SD: 1.62), GM: 2.1 times (SD: 1.29), KM: 4.5 times (SD: 3.74), NM: 2.2 times (SD: 1.47), PG: 2.2 times (SD: 2.24), SM: 4.6 times (SD: 3.64), TM: 3.8 times (SD: 3.06), TS: 2.5 times (SD: 1.54).

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