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數種의 藥物이 初期茵苔의 酸形成에 미치는 影響에 關한 實驗的 硏究

THE EFFECTS OF SOME DRUGS ON THE ACID PRODUCTION OF THE DENTAL PLAQUE IN VITRO

대한구강생물학회지 1977년 1권 1호 p.7 ~ 13
김관식,
소속 상세정보
김관식 (  ) - 서울대학교 대학원 의과대학 구강해부학

Abstract


This experiment was performed to study the effects of some antibiotics, fluorides, Ginseng extracts and fraction and antiseptics on the acid production of the dental plaque of early stage.
In vitro plaque, which had similar microbial and glycolytic characteristics to those of the plaque, in vivo, was formed on Brain-Heart Infusion agar-coated slides from 4times concentrated salivary sediment suspension by rotating them through the salivary sediment suspension at the velocity of 1 revolution/2min for 1 hour.
To determine the effects of the drugs, 0.5㎖ of drug solutions were added to 4.5㎖ of salivary sediment suspension to produce the desired concertration while 0.5㎖ sterile distilled water was added for control group.
And then plaque slides were placed in 3㎖ of 1% glucose solution and their acid production were measured by means of pH after 0, 6, 9, 12 hours of incubation period at 37℃.
The drugs employed for this study were kanamycin, streptomycin, gentamicin, cephaloridine, NaF, SnF_(2), Ginseng water and methanol extracts, crude saponin fraction, benzalkalonium chloride and povidone-iodine. The results were as follows:
1) Above the level of 10㎍/㎖, kanamycin, streptomycin, gentamicin, cephaloridine exerted similar inhibitory effect significantly and at 1㎍/㎖ level, cephaloridine was more effective but its duration was shorter than others.
2) Fluorides inhibited acid production, but at each concentration, SnF_(2) was more effective than NaF.
3) Ginseng water extract inbibited acid production slightly at 1% level and methanol extract did not exert inhibitony effect. But crude saponin fraction enhanced the acid production at 0.5% and above.
4) Benzalkalonium and povidone-jodane inhbited the acid production markedly at the level of 0.1%.

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