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Undifferentiated pleomorphic sarcoma of the mandible

대한구강악안면외과학회지 2020년 46권 4호 p.282 ~ 287
Benites Bernar Monteiro, Miranda-Silva Wanessa, Fonseca Felipe Paiva, de Oliveira Claudia Regina Gomes Cardim Mendes, Fregnani Eduardo Rodrigues,
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 ( Benites Bernar Monteiro ) - Hospital Sirio Libanes Department of Oral Medicine
 ( Miranda-Silva Wanessa ) - Hospital Sirio Libanes Department of Oral Medicine
 ( Fonseca Felipe Paiva ) - Universidade Federal de Minas Gerais School of Dentistry Department of Oral Surgery and Pathology
 ( de Oliveira Claudia Regina Gomes Cardim Mendes ) - Hospital Sirio Libanes Department of Pathology
 ( Fregnani Eduardo Rodrigues ) - Hospital Sirio-Libanes Departament of Oral Medicine

Abstract


Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindlecell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.

키워드

Soft tissue sarcoma; Pleomorphic sarcoma; Malignant fibrous histiocytoma; Oral cavity; Mandible

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