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Cytosine Arabinoside가 흰쥐 下顎頭軟骨의 成長에 미치는 影響에 關한 硏究

A Study of the Effects of Cytosine Arabinoside on the Growth of Mandibular Condylar Cartilage in Rat

대한구강해부학회지 1977년 1권 1호 p.15 ~ 20
우형식,
소속 상세정보
우형식 (  ) - 서울대학교 대학원 치의학과 구강해부학 전공

Abstract


A total of 40 male rats weighing 30gm each were used throughout these experiments.
Experimental animals were given an intramuscular injection of cytisine arabinoside 25mg per kg of body weight. The animals were sacrificed 3,5,8,12, and 18 days after injection of the cytosine arabinoside.
Mandibular condylar cartilages were removed under ether anesthesia prom rats. For routine light microscopy, the condyles were fixed in 10 per cent formalin for 3 days, decalcified in 10 percent versene for two weeks, embedded in parlodion and paraplast, and stained with H & E and toluidine blue O.
The present study was initiated to evaluate the effects of the cytosine arabinoside on the mandibular condylar cartilage of rat by histometric measurements.
The results were as follows:
1. The effects of cytosine arabinoside on the thickness of mandibular condylar cartilage were most pronounced on day 3 followed by a gradual recovery thereafter.
2. In the histological findings of the mandibular condylar cartilage of rat after injection of cytosine arabinoside for 3 days, proliferative zone showed lack the normal basophilia and decreased mitotic activity. There was a significantly decreased number of cells and many of cells were irregularly formed.
3. The result is interpreted to indicate that nucleic acid and mitotic activity in mandibular condylar cartilage are immediately suppressed by cytosine, arabinoside and that such suppression might lead to a later disturbance among these growing condylar cartilage.

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