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에스상결장과 직장에서 발생한 암에서 말초혈액, 하장간막정맥, 담즙 및 복강액 CEA의 임상적 중요성

Clinical Significance of CEA Level of Peripheral Vein, Inferior Mesenteric Vein, Bile, and Peritoneal Fluid in Sigmoid Colon and Rectal Cancer

대한대장항문학회지 2000년 16권 4호 p.239 ~ 246
이주영, 김정용, 김재한, 박상헌, 박정희, 변주남,
소속 상세정보
이주영 ( Lee Ju-Young ) - 조선대학교 의과대학 외과학교실
김정용 ( Kim Jung-Young ) - 조선대학교 의과대학 외과학교실
김재한 ( Kim Jae-Han ) - 조선대학교 의과대학 외과학교실
박상헌 ( Park Sang-Heon ) - 조선대학교 의과대학 외과학교실
박정희 ( Park Jung-Hee ) - 조선대학교 의과대학 외과학교실
변주남 ( Byun Joo-Nam ) - 조선대학교 의과대학 방사선과학교실

Abstract


Purpose: Carcinoembriogenic antigen (CEA) was widely used as a marker for staging and detection of recurrence and metastases, and evaluation of response of radical opertion or chemotherapy in colorectal cancer patients.

Methods: We examined 50 patients with sigmoid colon and rectal cancer patients who had a radical operation between 1994 May and 1995 April. We checked the level of CEA of peripheral blood preoperatively and postoperatively, and inferior mesenteric vein, bile of gall bladder and peritoneal fluid during surgery. We review clinical characters of the patients, and analyzed the importance of CEA level.

Results: The mean CEA levels of peripheral blood (postoperation), inferior mesenteric vein, bile, peritoneal fluid were 5.35 2.65, 13.23 2.13, 9.23 1.65, 7.42 2.34 ng/ml respectlively. The mean CEA level of inferior mesentiric vein (13.23 2.13 ng/ml) was significantly higher than that of preoperative peripheral blood (8.13 2.34 ng/ml) (p<0.05). Falling of postoperative peripheral blood CEA level was also significantly lower than that of preoperative level (p< 0.05).

Conclusion: Level of postoperative peripheral blood was related to recurrence rate and survival rate, but tumor size, tumor location, tumor differentiation, Dukes’ stage were not related to the CEA level. Bile and peritoneal fluid CEA levels were related with the liver metastasis or local recurrence respectively. We suggest that CEA was useful indicator for evaluation, management, and prognosis of colorectal cancer not only preoperatively but also postoperatively

키워드

CEA;Colorectal cancer;Peripheral blood;Bile;Peritoneal fluid;Prognosis

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