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대장암에서 Cyclooxygenase-2의 발현

Expression of Cyclooxygenase-2 in Colorectal Adenocarcinoma

대한대장항문학회지 2001년 17권 5호 p.259 ~ 266
김형석, 허태길, 홍성우, 주미, 장여구, 권도성, 백인욱, 이혁상,
소속 상세정보
김형석 ( Kim Hyung-Seok ) - 인제대학교 서울백병원 외과학교실
허태길 ( Heo Tae-Kil ) - 인제대학교 서울백병원 외과학교실
홍성우 ( Hong Seong-Woo ) - 인제대학교 의과대학 서울백병원 외과학교실
주미 ( Joo Mee ) - 인제대학교 의과대학 병리학교실
장여구 ( Chang Yeo-Goo ) - 인제대학교 의과대학 서울백병원 외과학교실
권도성 ( Kwon Do-Sung ) - 인제대학교 서울백병원 외과학교실
백인욱 ( Paik In-Wook ) - 인제대학교 의과대학 서울백병원 외과학교실
이혁상 ( Lee Hyuck-Sang ) - 인제대학교 의과대학 서울백병원 외과학교실

Abstract


Purpose: Several studies indicate that nonsteroidal anti- inflammatory drugs including aspirin and sulindac reduce the risk of colon cancer. Futhermore, nonsteroidal anti-inflammatory drugs that inhibit the cyclooxygenase (COX) are shown to inhibit the development colon cancer in animal models of carcinogenesis. COX-1 is constitutively expressed to fulfill its beneficial housekeeping roles. COX-2 is not constitutively expressed by most normal tissues, but it is rapidly induced by certain inflammatory cytokines, tumor promoters, growth factors and oncogenes. The purpose of this study is to evaluate the role of COX-2 in colorectal carcinoma development and the correlation between COX-2 expression and tumor angiogenesis and p53 overexpression.

Methods: Immunohistochemical analyses using antibodies against COX-2, factor VIII-related antigen, vascular endothelial growth factor (VEGF) and p53 were carried out on archival specimens of 15 colorectal adenoma and 41 adenocarcinoma.

Results: COX-2 expression was increased in 5/15 (33.3%) adenomas and 24/41 (58.5%) adenocarcinomas. COX-2 expression in adenocarcinoma was nearly significantly higher than in adenoma (P=0.050). In adenocarcinoma, COX-2 expression was increased in early cancer (TNM stage) (P=0.028) and well differentiated tumor (P=0.029). COX- 2 expression was not correlated with VEGF expression, microvessel density and p53 overexpression.

Conclusion: These findings indicate that enhanced expression of COX-2 occurs early during colorectal cancer progression. However, further investigations are needed to evaluate the relationship of COX-2 and tumor angiogenesis using other laboratory methods.

키워드

COX-2 대장암;면역조직화학 염색
COX-2 Colorectal cancer;Immunohistochemical staining

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