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대장직장암에서 p53 및 Ki-67 발현의 임상적 의의

Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer

대한대장항문학회지 2009년 25권 2호 p.107 ~ 112
허정욱, 김형록, 조상혁, 김영진,
소속 상세정보
허정욱 ( Huh Jung-Wook ) - 전남대학교 의과대학 화순전남대학교병원 외과
김형록 ( Kim Hyeong-Rok ) - 전남대학교 의과대학 화순전남대학교병원 외과
조상혁 ( Cho Sang-Hyuk ) - 전남대학교 의과대학 화순전남대학교병원 외과
김영진 ( Kim Young-Jin ) - 전남대학교 의과대학 화순전남대학교병원 외과

Abstract


Purpose: This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.

Methods: Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters.

Results: Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables.Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).

Conclusions: Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.

키워드

p53;Ki-67;대장암
p53;Ki-67;Colorectal cancer

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