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Value and Interpretation of Resection Margin after a Colonoscopic Polypectomy for Malignant Polyps

대한대장항문학회지 2011년 27권 4호 p.194 ~ 201
장은정, 김대동, 조창호,
소속 상세정보
장은정 ( Jang Eun-Jung ) - Catholic University of Daegu College of Medicine Department of Surgery
김대동 ( Kim Dae-Dong ) - Catholic University of Daegu College of Medicine Department of Surgery
조창호 ( Cho Chang-Ho ) - Catholic University of Daegu College of Medicine Department of Pathology

Abstract


Purpose: This study was designed to compare the clinicopathologic findings of an endoscopic polypectomy for malignant polyps with subsequent surgery and to evaluate the appropriateness of the pathologic finding criterion of the resection margin as an indicator for surgery in cases of malignant colorectal polyps.

Methods: We examined the clinicopathologic characteristics, complications and prognoses among the patients who underwent a colonoscopic polypectomy in both our hospitals and at other hospitals from April 2003 and April 2010. These patients were divided into two groups, the group (non-operation group) that only underwent a polypectomy (n = 37) and the group (operation group) that underwent a polypectomy with subsequent surgery (n = 33).

Results: There were no differences between two groups in the ratios of the number of men to the number of women, the ages or the comorbidities. In terms of endoscopic findings, we found no differences between the two groups in the locations of the polyps, the sizes of the polyps, or the presence of stalks. However, ulceration of polyps was higher in the non-operation group (51.5% vs. 21.6%; P = 0.009), as was the case with submucosal invasion (75.8% vs. 16.2%; P < 0.005). When an endoscopic polypectomy was performed, incomplete resection margins and specimens with margins involved occurred more frequently in the operation group (93.9% vs. 51.4%; P < 0.005), but no residual tumor was detected in 31 of 33 (93.9%) patients in that group. One pathologist reviewed the specimens of 54 patients (operation group, 19; non-operation group, 36). Six of the 19 polyps (31.6%) in the operation group and fifteen of the 36 polyps (41.7%) in the non-operation group had a margin without cancer cells.

Conclusion: We may accept the criterion of a safe margin, including a coagulation zone. A multidisciplinary approach has to be developed by surgeons, endoscopists and pathologists based on a discussion of the risk factors for the patient before making a decision on the treatment treatment.

키워드

Malignant colorectal polyp;Endoscopic Resection criteria;Resection margin

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