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Clinical Applications of Radio-Frequency Ablation in Liver Metastasis of Colorectal Cancer

대한대장항문학회지 2011년 27권 4호 p.202 ~ 210
Gwak Ji-Hun, 오보영, 이아령, 정순섭, 김광호,
소속 상세정보
 ( Gwak Ji-Hun ) - Ewha Womans University School of Medicine Department of Surgery
오보영 ( Oh Bo-Young ) - Ewha Womans University School of Medicine Department of Surgery
이아령 ( Lee Ah-Ryung ) - Ewha Womans University School of Medicine Department of Surgery
정순섭 ( Chung Soon-Sup ) - Ewha Womans University School of Medicine Department of Surgery
김광호 ( Kim Kwang-Ho ) - Ewha Womans University School of Medicine Department of Surgery

Abstract


Purpose: The aim of this study is to evaluate long-term survival and prognostic factors for radio-frequency ablation (RFA) in colorectal liver metastases.

Methods: We retrospectively reviewed 35 colorectal liver metastases patients who underwent RFA between 2004 and 2008. We analyzed survival after RFA and prognostic factors for survival.

Results: Of the 35 patients, 23 patients were male and 12 were female. Their mean age was 62.40 ± 12.52 years. Mean overall survival was 38.8 ± 4.6 months, and mean progression free survival was 19.9 ± 3.4 months. Three- and 5-year overall survival rates were 42.7 ± 0.1% and 26.0 ± 0.1%, respectively. Three- and 5-year progression-free survival rates were 19.6 ± 0.1% and 4.9 ± 0.04%, respectively. Overall survival and progression-free survival were significantly improved in male and in patients with carcinoembryonic antigen (CEA) ≤ 100 ng/mL, carbohydrate antigen (CA) 19-9 ≤ 100 ng/mL, absence of extrahepatic disease, and a unilobar hepatic lesion. In addition, progression-free survival was improved in patients with a solitary hepatic lesion. On the multivariate analysis, significant survival factors were the absence of extrahepatic disease and the presence of a unilobar hepatic lesion.

Conclusion: RFA for colorectal liver metastases is an effective treatment option in male patients and in patients with CEA or CA19-9 ≤ 100, absence of extrahepatic disease, a solitary hepatic lesion, and a unilobar hepatic lesion.

키워드

Radiofrequency ablation;Colorectal liver matastasis;Survival;Prognostic factor

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