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小量 Atropine이 心搏數에 미치는 影響

Effect of Small Dose Atropine on Cardiac Rate in Rabbits

대한마취과학회지 1969년 2권 1호 p.29 ~ 33
최수홍,
소속 상세정보
최수홍 (  ) - 서울대학교 의과대학 마취과학교실

Abstract


In rabbits:
(1) Intravenous atropine in the dose of 0.002-0.004 mg/kg caused bradycardia, whereas in that exceeding 0.02 mg/kg tachycardia. Transient but alarming degrees of tachycardia could be observed when 2 mg/kg dose was employed.
(2) While Arfonad was being infused, the heart rate changed little regardless of the doses of atropine used
(3) During Arfonad drip, changes in heart rate seemed fairly well correlated with the degree of hypotension, i.e., magnitude of ganglionic blockade.
(4) The above findings suggest that, at least in rabbits, small dose atropine-induced cardiac slowing is due to the inhibitory action of atropine on the sympathetic ganglia. This cannot, however, be directly applied to human physiology because of the possible species difference in the regulatory mechanisms of heart rate.

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