잠시만 기다려 주세요. 로딩중입니다.

Remeflin^(®)의 呼吸促進作用의 機轉에 關한 實驗的 硏究

An Experimental Study on the Mechanism of Respiratory Stimulation by Remeflin^(®)

대한마취과학회지 1976년 9권 1호 p.9 ~ 15
李健一, 郭一龍,
소속 상세정보
李健一 (  ) - 서울대학교 醫科大學 麻醉科學敎室
郭一龍 (  ) - 서울대학교 醫科大學 麻醉科學敎室

Abstract


To ten male volunteers, 25 to 35 years old and without any known disease, physiological saline solution (placebo) 1 ml, ortphine 10 ㎎, and Remaflin 16 ㎎ were administered intramuscularly. Effects of these agents upon ventilation at rest and respiratory response to carbon dioxide rebreathing were studied.
The results are as follows:
1) Morphine significantly decreased respiratory rate, minute volume, and Pao₂and increased Paco₂without signivicantly affecting either tidal volume or arterial pH.
2) In morphine-induced respiratory depression, Remeflin improved ventilation by significantly increasing tidal volume and minute volume with resultant increase in Pao₂and decrease in Paco₂. Remeflin did not significantly alter respiratory rate and arterial pH.
3) Morphine displaced respiratory response curve to carbon dioxide obtained with placebo 7 torr to the right and Remeflin 6 torr to the left.
No changes in slope of the curves were observed.
4) It is concluded that Remeflin stiraulates respiration by directly acting upon the respiratory center.

키워드

원문 및 링크아웃 정보

 

등재저널 정보

KCI
KoreaMed
KAMS