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Succinylcholine Chloride의 정맥주사시 경골골절 가토의 혈청 Potassium의 변화

Serum Potassium Changes in Tibial Fracture of Rabbits from Intravenous Succinylcholine Chloride

대한마취과학회지 1977년 10권 1호 p.59 ~ 64
유승아, 이형진,
소속 상세정보
유승아 (  ) - 가톨릭대학교 의과대학 마취과학교실
이형진 (  ) - 가톨릭대학교 의과대학 마취과학교실

Abstract


The use of the succinylcholine chloride for endotracheal intubation is a widely accepted technic during induction of inhalational anesthesia.
Currently transient hyperkalemia is well known to occur in man following intravenous administration of succinylcholine chloride. Furthermore, the massive hyperkalemia following succinylcholine chloride administration is a recognized danger in patients with severe burns, massive trauma, muscle dystrophy and skeletal muscle paralysis caused by peripheral nerve injury or lesions of the central nervous system.
Increased serum potassium may lead to severe cardiac arrhythmia or cardiac arrest.
We studied the effect of intravenously administered succinylcholine chloride on the serum potassium level and electrocardiographic changes in nontraumatized and traumatized (fractured tibia) rabbits.
The following results were obtained:
1. Serum potassium was slightly increased in the non-traumatized group and slightly decreased in the traumatized group before succinylcholine chloride injection, after 5 minutes of succinyl choline chloride injection and after 10 minutes of succinylcholine chloride injection but no statistical significance was noticed in either group.
w. Serum calcium was significantly decreased in the traumatized group after intravenous succinylcholine chloride. (p<0.05)
3. Hemoglobin and hematocrit were decreased in both non-traumatized and traumatized groups due to blood loss during the studies.
4. In the non-graumatized group, the incidence of arrhythmia was increased from 25% to 40% and incidence of arrhythmia in the traumatized group was the same, 53.3% before and after succinylcholine chloride injection.

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