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家兎에서 Succinylcholine이 頭蓋內壓 및 血壓에 미치는 影響

Effects of Suceinylcholine on the Intracranial Pressure and Blood Pressure in Rabbits

대한마취과학회지 1977년 10권 3호 p.17 ~ 22
河仁鎬, 金庚鎬,
소속 상세정보
河仁鎬 (  ) - 全南大學校 醫科大學 麻醉科學敎室
金庚鎬 (  ) - 全南大學校 醫科大學 麻醉科學敎室

Abstract


1. In urethane-anesthetized rabbits, effects of intravenous injections of succinylcholine (1,3,10,30 ㎎/㎏) on intracranial pressure (ICP) and blood pressure were observed.
2. When ICP was not elevated, single doses of 1.3 and 10 ㎎/㎏ of succinylcholine did not affect BP, but 30 ㎎/㎏ produced slight elevation of BP.
The repeated doses(3 times with intervals of 1 min) of 1 and 3 ㎎/㎏ did not affect BP, but the repeated doses of 10 ㎎/㎏ produced elevation of BP in part of the experiments.
3. When ICP was elevated to 30∼40 mmHg, ICP was not effected by single doses of succinylcholine, but BP was elevated by 10 and 30 ㎎/㎏. The repeated doses of succinylcholine did not affect ICP, but repeated doses of 10 ㎎/㎏ produced elevation on BP in part of the experiments.
4. When ICP was elevated to 50∼70 mm Hg, ICP was not affected by single doses of 1.3 and 10 ㎎/㎏, but was slightly elevated by 30 ㎎/㎏. BP was elevated by 10 and 30 ㎎/㎏. The repeated doses of 1.3 and 10 ㎎/㎏ produced little elevation of ICP, but repeated doses of 10 ㎎/㎏ produced marked elevation of BP.
5. It is suggested that acutely elevated ICP does not increase further by succinylcholine.

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