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人體氣管에서 分離한 Aspergillus의 Mouse臟器에 對한 病原性에 관한 硏究

Pathogenicity in Mice of Aspergillus Species Identified from Human Trachea

대한마취과학회지 1977년 10권 3호 p.43 ~ 50
윤병래, 김익수, 최세진, 장명웅, 이미정,
소속 상세정보
윤병래 (  ) - 충남대학교 의과대학 마취과학교실
김익수 (  ) - 충남대학교 의과대학 마취과학교실
최세진 (  ) - 충남대학교 의과대학 마취과학교실
장명웅 (  ) - 충남대학교 의과대학 미생물학교실
이미정 (  ) - 충남대학교 의과대학 병리학교실

Abstract


Attempts were made to investigate the pathogenicity of the aspergillus species by innoculating normal mice intravenously with aspergillus suspension, 10^(5) spores/ml and 5×10^(4) spore/ml concentration and as a comparison group, concentration of hormodendrum suspension 5×10^(4) spore/ml.
The following results were obained.
1) High peak mortality (51.5%) was seen at the 5th and 6th day after innoculation.
2) Cause of death was suspected as infection of the kidney.
3) Aspergillus species(mortality, 94.2%) has shown more pathogenicity than hormodendrum group (mortality 25%).
4) The main pathological changes were: in lung, 63% congestion, 37% inflammation, in liver, 63% congestion, 19% inflammation, in heart, 60% congestion, 26% inflammation, and in kidney, 81% inflammation, 52% congestion.
5) On identification of fungus with PAS stain, there were 9 cases in kidney (25.7%) and 1 case in heart (2.85).

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