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Ether 및 Halothane마취시 정맥혈에서의 Lactate, Pyruvate 및 Excess lactate치의 변화에 대한 연구

Lactate, Pyruvate and Excess Lactate in Venous Blood during Ether and Halothane Anesthesia

대한마취과학회지 1977년 10권 3호 p.57 ~ 61
김익수, 한봉헌, 백문기, 황병두,
소속 상세정보
김익수 (  ) - 충남대학교 의과대학 마취과학교실
한봉헌 (  ) - 충남대학교 의과대학 마취과학교실
백문기 (  ) - 충남대학교 의과대학 마취과학교실
황병두 (  ) - 충남대학교 의과대학 병리학교실

Abstract


Venous blood lactate, pyruvate and excess lactate have been measured by the enzymatic method and calculated in 24 patients over a period of 2 hours during operation under general anesthesia.
When the anesthetic was diethyl, ether, lactate and dyruvate levels showed a gradual increase significantly from 30 minutes and 60 minutes after induction of anesthesia respectively. Excess lactate appeared 30 minuts after induction of anesthesia, being increased slightly thereafter.
When halothane was used, lactate level rose significantly in 120 minutes but no significant change in pyruvate and excess lactate was observed.
In comparison to the results obtained in arterial blood during ether anesthesia by others, the levels of lactate and pyruvate found in this study were higher than those observed in arterial blood, whereas there was no considerable difference in change with duration of anesthesia and excess lactate.
From the above results we suggested that venous blood lactate, pyruvate and excess lactate were essentially the same as those of arterial blood for evaluating tissue hypoxia during general anesthesia.

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