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Effect of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation: a randomized control trial

대한마취과학회지 2021년 74권 2호 p.150 ~ 157
Misra Satyajeet, Behera Bikram Kishore, Mitra Jayanta Kumar, Sahoo Alok Kumar, Jena Sritam Swarup, Srinivasan Anand,
소속 상세정보
 ( Misra Satyajeet ) - All India Institute of Medical Sciences Department of Anaesthesia and Critical Care
 ( Behera Bikram Kishore ) - All India Institute of Medical Sciences Department of Anaesthesia and Critical Care
 ( Mitra Jayanta Kumar ) - All India Institute of Medical Sciences Department of Anaesthesia and Critical Care
 ( Sahoo Alok Kumar ) - All India Institute of Medical Sciences Department of Anaesthesia and Critical Care
 ( Jena Sritam Swarup ) - All India Institute of Medical Sciences Department of Anaesthesia and Critical Care
 ( Srinivasan Anand ) - All India Institute of Medical Sciences Department of Pharmacology

Abstract


Background: Dexmedetomidine, an alpha-2 agonist, has been used for attenuation of hemodynamic response to laryngoscopy but not through the nebulized route. We evaluated the effects of preoperative dexmedetomidine nebulization on the hemodynamic response to laryngoscopy and intubation and examined the intraoperative anesthetic-analgesic requirements and recovery outcomes.

Methods: Overall, 120 American Society of Anesthesiologists I & II adult patients (of either gender) undergoing elective surgeries and requiring tracheal intubation, were randomized to receive nebulized dexmedetomidine (1 μg/kg in 3?4 ml of 0.9% saline) or 0.9% saline (3?4 ml), 30 min before anesthesia induction. Heart rate (HR) and non-invasive systolic blood pressure (SBP) were monitored for 10 min following laryngoscopy.

Results: After laryngoscopy, linear mixed effect modelling showed significantly lower trend of increase in HR in the dexmedetomidine group versus saline (P = 0.012); however, there was no difference in the SBP changes between the two groups (P = 0.904). Induction dose of propofol (P < 0.001), intraoperative fentanyl consumption (P = 0.007), and isoflurane requirements (P = 0.013) were significantly lower in the dexmedetomidine group. There was no difference in the 2 h incidence of postoperative nausea and vomiting (PONV) (P = 0.612) or sore-throat (P = 0.741).

Conclusions: Nebulized dexmedetomidine at 1 μg/kg attenuated the increase in HR but not SBP following laryngoscopy and reduced the intraoperative anesthetic and analgesic consumption. There was no effect on early PONV, sore-throat, or increase in incidence of adverse effects. Nebulized dexmedetomidine may represent a favorable alternative to the intravenous route in short duration surgeries.

키워드

Dexmedetomidine; Hemodynamics; Inhalation; Intravenous anesthetics; Intubation; Laryngoscopy

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