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장내 세균의 약제내성

Resistance of Enterobacteriaceae to Antibacterial drugs

대한미생물학회지 1970년 5권 1호 p.27 ~ 31
河大有,
소속 상세정보
河大有 (  ) - 전남대학교 의과대학 세균학교실

Abstract


Nalidixic acid and six other drugs were studied for in vitro effectiveness against 200 strains of Escherichia coli isolated recently from healthy persons and bactericidal activity of ampicillin against one respective strain of Escherichia coli and Salmonella typhi isolated were also studied.
The results obtained by the plate dilution method showed the following percentage of resistance: kanamycin, 2.5%; streptomycin, 12.0%; ampicillin, 13.5%; tetracycline, 15.5%; chloramphenicol, 17.5%; colistin sulfate, 19.5%. No strains were resistant to nalidixic acid, clearly indicating that nalidixic acid is the most effective drug tested.
Ampicillin, measured by test-tube diltion method, was highly bactericidal against Salmonella typhi at the concentration of 2.5 mcg/ml and against Escherichia coil at 5 mcg/ml.

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