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비 인두암 체적 조절 호형 방사선 치료의 선량 계산 격자 크기에 따른 선량 체적 지수와 방사선 생물학적 지수의 평가

Evaluation of Dose Volume and Radiobiological Indices by the Dose Calculation Grid Size in Nasopharyngeal Cancer VMAT

방사선기술과학 2020년 43권 4호 p.265 ~ 272
강동진, 정재용, 신영주, 민정환, 심재구, 박소현,
소속 상세정보
강동진 ( Kang Dong-Jin ) - Inje University Sanggye Paik Hospital Department of Radiation Oncology
정재용 ( Jung Jae-Yong ) - Inje University Sanggye Paik Hospital Department of Radiation Oncology
신영주 ( Shin Young-Joo ) - Inje University Sanggye Paik Hospital Department of Radiation Oncology
민정환 ( Min Jung-Whan ) - Shingu University Department of Radiological Technology
심재구 ( Shim Jae-Goo ) - Daegu Health College Department of Radiologic Technology
박소현 ( Park So-Hyun ) - Jeju National University Hospital Department of Radiation Oncology

Abstract


The purpose of this study was to investigate the dose-volume indices and radiobiological indices according to the change in dose calculation grid size during the planning of nasopharyngeal cancer VMAT treatment. After performing the VMAT treatment plan using the 3.0 ㎜ dose calculation grid size, dose calculation from 1.0 ㎜ to 5.0 ㎜ was performed repeatedly to obtain a dose volume histogram. The dose volume index and radiobiological index were evaluated using the obtained dose volume histogram. The smaller the dose calculation grid size, the smaller the mean dose for CTV and the larger the mean dose for PTV. For OAR of spinal cord, brain stem, lens and parotid gland, the mean dose did not show a significant difference according to the change in dose calculation grid size. The smaller the grid size, the higher the conformity of the dose distribution as the CI of the PTV increases. The CI and HI showed the best results at 3.0 ㎜. The smaller the dose calculation grid size, the higher the TCP of the PTV. The smaller the dose calculation grid size, the lower the NTCP of lens and parotid. As a result, when performing the nasopharynx cancer VMAT plan, it was found that the dose calculation grid size should be determined in consideration of dose volume index, radiobiological index, and dose calculation time. According to the results of various experiments, it was determined that it is desirable to apply a grid size of 2.0 ? 3.0 ㎜.

키워드

선량 계산 격자 크기; 조형 지수; 균일 지수; 종양 제어 확률; 정상 조직 합병증 확률
Dose calculation grid size; Conformity index (CI); Homogeneity index (HI); Tumor control probability (TCP); Normal tissue complication probability (NTCP)

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