잠시만 기다려 주세요. 로딩중입니다.

Iopamidol과 Ioversol 제제 조영제의 온도변화에 따른 물리화학적 분석

Physicochemical Analysis according to Temperature Changes of Iopamidol and Ioversol Formulation Contrast Agents

방사선기술과학 2020년 43권 4호 p.273 ~ 280
한범희,
소속 상세정보
한범희 ( Han Beom-Hee ) - Radiation Science Technology Laboratory R&D Team

Abstract


In this study, the P contrast agent of Iopamidol, which is a nonionic iodide contrast agent most commonly used as a vascular contrast agent in medical institutions, and the O contrast agent of Ioversol, were studied. The physicochemical changes according to the temperature change were compared and analyzed using the Bruker Avance 500MHz Nuclear Magnetic Resonance Spectrometer owned by the Korea Basic Science Institute (KBSI). There was no physical or chemical change in the O contrast medium of Ioversol formulation in temperature change. However, in the P contrast agent of Iopamidol, a doublet peak began to appear in the 1.1 ppm region of the sample at 60℃, and the doublet peak was clearly observed in the sample at 80℃. As a result of this study, 1H-NMR analysis revealed that the P contrast agent of the Iopamidol formulation was dissociated from chemical bonds as it rose to a high temperature of 60℃ or higher, resulting in the formation of foreign substances. It was evaluated that the O contrast agent of Ioversol formulation had physico-chemical stability than the P contrast agent of Iopamidol formulation. As shown in this study, it is necessary to analyze the physical and chemical changes of contrast agents according to various environmental factors.

키워드

요오드화 조영제; Iopamidol; Ioversol; 핵자기공명분광법; 온도변화
Contrast Agents; Iopamidol; Ioversol; NMR; Temperature changes

원문 및 링크아웃 정보

 

등재저널 정보