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Intentional Death Caused by the Overdose of Nonprescription Drugs: An Autopsy Case of Acetaminophen Poisoning

대한법의학회지 2020년 44권 3호 p.134 ~ 139
김미림, 이숭덕, 김문영,
소속 상세정보
김미림 ( Kim Mi-Lim ) - Seoul National University Bundang Hospital Department of Pathology
이숭덕 ( Lee Soong-Deok ) - Seoul National University College of Medicine Department of Forensic Medicine
김문영 ( Kim Moon-Young ) - Seoul National University College of Medicine Institute of Forensic and Anthropological Science

Abstract


Acetaminophen or paracetamol (N-acetyl-para-aminophenol [APAP]) is a safe and effective antipyretic and analgesic drug and is a representative nonprescription drug. However, APAP is one of the most common nonprescription drugs used for intentional overdose or suicide, thereby resulting in hundreds of deaths annually in the United States. Moreover, the misuse of nonprescription drugs is a cause of increasing concern in Korea with the revision of the Pharmaceutical Affairs Law in 2012. Generally, the mortality rate of APAP overdose is extremely low due to the well-established treatment guidelines and availability of antidotes. However, it should not be overlooked because of the high number of either accidental or intentional APAP overdose cases recorded every day. To achieve a good prognosis, individuals with APAP overdose must be immediately identified and brought to the hospital. Herein, we report an autopsy case of an individual with APAP overdose who died due to acute liver injury.

키워드

Nonprescription drugs; Acetaminophen; Drug-induced acute liver injury; Suicide; KIDS KAERS database (KIDS-KD)

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