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거식세포내에 탐식된 Salmonella typhi에 대한 항생제의 영향

The Effect of Antibiotics on Salmonella typhi Ingested by Macrophages

대한병리학회지 1976년 10권 1호 p.143 ~ 148
박효용, 박정자, 서강석, 김명남,
소속 상세정보
박효용 (  ) - 경북대학교 의과대학 임상병리학교실
박정자 (  ) - 경북대학교 의과대학 임상병리학교실
서강석 (  ) - 경북대학교 의과대학 임상병리학교실
김명남 (  ) - 경북대학교 의과대학 임상병리학교실

Abstract


The authors studied the effect of antibiotics on Salmonella typhi Ty2 ingested by
macrophages, which were obtained from the peritoneal cavities of two male rabbits.
The applied antibiotics were ampicillin, chloramphenicol and bactrim.
The antibiotic effect was determined with the viable bacterial numbers in the macro-
phages at 6, 12, 24, 36, 48 and 72 hour-cultivation.
The results were summarized as follows :
1. Salmonella typhi Ty2 ingested by macrophages were slightly protected from the
killing action of antibiotics than the same organisms not ingested by macrophages.
2. The killing action of ampicillin was slightly decreased, when it combined with
other antibiotics. The synergic action of chloramphenicol and bactrim was not observed.

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