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혈장 Protransglutaminase(혈액응고인자 XIII)의 생산에 관한 연구

Biosynthesis of Plasma Protransglutaminase (Blood Coagulation Factor XIII)

대한병리학회지 1978년 12권 2호 p.171 ~ 174
이수영, 조형래,
소속 상세정보
이수영 (  ) - Chungbuk National University
조형래 (  ) - 가톨릭대학 의학부 병리학교실

Abstract


Transglutaminase from its zymogen, blood coagulation Factor XIII, catalyzes the
covalent intermolecular polymerization of fibrin through formation of ε (γ-glutamyl)
lysine crosslink. In recent years, considerable progress has been made in understanding
the molecular and catalytic Properties of Factor XIII. However, the metabolic aspects of
Factor XIII under various physiological conditions are not fully understood. Lee and
Chung (1976) elucidated that plasma protransglutaminase is synthesized in hepatocytes.
In this report we observed the mode of synthesis and the secretion of plasma pro-
transglutaminase in vivo. Rabbits were used as the experimental model.
The results were as follows :
1, Both a and b-chains incorporated by [75Se] -L-methionine in the liver
showed their maximum values at 30 minutes after [75Se] -L-methionine
infusion, then the values continued to decrease up to 2 hours, followed by plateau of 4
hours, whereas those in the plasma rapid1y increased up to 3 hours, and then showed a
plateau. Plasma fibrinogen showed the same pattern as that of plasma protrans-
glutaminase.
2. B-chains were formed and secreted at a much larger rate than a-chains.
3. Protransglutaminase was formed and secreted at a much larger rate than fibrinogen.

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