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부산 지방의 원발성 간세포암 환자에 있어서 α-Fetoprotein과 HBsAg에 관한 연구

Study on Serum Alpha-fetoprotein and Hepatitis B Surface Antigen in Primary Liver Cell Carcinoma in Busan Area

대한병리학회지 1978년 12권 4호 p.419 ~ 426
손한철, 김순호,
소속 상세정보
손한철 (  ) - 부산대학교 치과대학 구강악안면외과학교실
김순호 (  ) - 부산대학교 의과대학 임상병리학교실

Abstract


The authors investigated the frequency of alpha-fetoprotein(AFP) and hepatitis B
surface antigen(HBsAg) in 135 cases of the primary hepatocellular carcinoma, clinically
and pathologically diagnosed in Busan National University Hospital and affiliated
hospitals in Busan during a period of 28 months from June 1976 to September 1978.
Serum AFP was detected by Ouchterlony microimmunodiffusion method and serum
HBsAg was detected by counterimmunoe lectrophoresis.
The results obtained were as follow:
1. Serum AFP was detected in 81(60%) out of 135 cases of primary hepatocellular
carcinoma but were not detected in all cases out of 331 of healthy person and 108 of
other liver diseases.
2. Serum HBsAg was detected in 16(11.9%) out of 135 cases of primary hepatocellular
carcinoma and in 15(4.5%) out of 351 cases of healthy control. The HBsAg postive rate
of the primary hepatocellular carcinoma was significantly higher than that of the healthy
control.
3. The serum HBsAg positive rates between the AFP positive and negative
hepatocellular carcinoma was not significantly different.
4. No influence of sex and age was found between AFP positive and negative
hepatocellular carcinoma and between HBsAg positive and negative hepatocellular
carcinoma between HBsAg positive and negative hepatobellular carcinoma
On the basis mentioned above, it is suggested that there is no correlation between
serum AFP and HBsAg in primary hepatocellular carcinoma.

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