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Clostridium perfringens로 인한 가스괴저 1예

Clostridium perfringens Gas Gangrene -A Case Report-

대한병리학회지 1978년 12권 4호 p.443 ~ 448
이동화, 최성희, 김선구,
소속 상세정보
이동화 (  ) - 연세대학교 의과대학 임상병리과
최성희 (  ) - 연세대학교 의과대학 임상병리과
김선구 (  ) - 연세대학교 의과대학 임상병리과

Abstract


Gas gangrene is a very rare infection nowadays because of perfection of aseptic
surgery, use of varieties of antibiotics and absence of war casualties. Recently we had a
case of gas gangrene developed following an open fracture, on a 44-year-old male. The
authors made bacteriological studies of the case and the result is presented together
with the clinical pictures.
1. Inspite of adequate treatment of the open fracture of his right femur and tibia, he
developed gas gangrene with typical signs such as severe myonecrosis, subcutaneous
vesicles and crepitus, erythematous changes of the skin and with symptoms of toxemia.
2. Gram stained smears of the exudate and tissue fragments from the lesion revealed a
large number of gram-positive bacilli. Culture of the specimens yielded Clostridium
perfringens which were with typical cultural and biochemical characteristics of the
species. Enterobacter and Klebsiella pneumoniae were concomitantly isolated from the
specimens.
3. Disk diffusion susceptibility test showed the Clostridium was susceptible to penicillin,
chloramphenicol, clindamycin, cephalothin, and tetracycline and resistant to erythromycin.
The above-knee amputation and then the hip disarticulation with the massive penicillin
and other antibiotics treatment were without effect and the patient expired on the 23rd
post operative day. This case demonstrated the severe nature of gas gangrene even in
the era of modern medicine.

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