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태반의 성숙과정에 대한 형태학적 관찰 A Morphological 騷(소)tu適(적)y on the Maturation Process of the 劉粃(유비)man Placenta

대한병리학회지 1979년 13권 4호 p.403 ~ 411
장자준, 장우현, 한준구,
소속 상세정보
장자준 (  ) 
서울대학교 의과대학 병리학교실

장우현 (  ) 
서울대학교 의과대학 병리학교실
한준구 (  ) 
서울대학교 의과대학 병리학교실

Abstract

The pathologist faced with the necessity for examining the placental tissue with a
wide variety of gestational ages needs certain criteria for the determination of
approximate gestational period in normal placentas. This knowledge enables one to be
aware of abnormalitieswhich could be physiological in certain period of gestation.
Authors. conducted a morphological study on 166 normal human placentas ranging
from 6weeds to 44 weeks. These placentas were classifies into 6 groups according to
gestationalperiod with the interval of 6 weeks. Gross and microscopic observations were
made and tabulated. They are summarized as follows.
1. Gross findings of the developing placenta were characterized by cotyledon formation
at the end of the 7th week, subchorionic fibrin deposit, fibrosis, tesselation and
Nitatuch layer, all of them appearing by 27 weeks gestation.
2. Microscopical characteristics consisted of endarteritis obliterans of the arterioles by 28
weeks, and intervillous fibrin deposit and thrombosis by 19 weeks of gestational wege.
3. Trophoblastic cells of the terminal villi stowed loBs of con沐(목)nuation after 13
weeks and eventually syncytial trophoblasts remain until full term. Syncytial knots
were seen after 20 weeks. Villous stroma changed from myxoid to fibrous nature by
19 weeks gestation.
4. Degenerative changes of the decidua were prominent by 28 weeks gestation, and re-
comprised of decidual necrosis, fibrin deposit and venous thrombosis.
In conclusion, sequential morphological changes of the developing human placentas
could enable us to determine the approximate gestational age for unknown placental
samples.

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