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글루타민酸 소다(Monosodium glutamate)가 人體에 미치는 細胞遺傳學的 影響에 關한 實驗的 硏究(豫報)

Cytogenetic Effects of Monosodium Glutamate on Human Cells in Vitro

대한산부인과학회지 1971년 14권 12호 p.3 ~ 6
張潤錫, 睦楨銀,
소속 상세정보
張潤錫 (  ) - 서울대학교 醫科大學 産婦人科學敎室
睦楨銀 (  ) - 서울대학교 醫科大學 産婦人科學敎室

Abstract


Human leucocytes were studied for chromosome breakage and other aberration´s in 66, presence of a´ ood- additive, monosodium glutamate, in vitro.
The agent- used in concentrations of 50, 100, 250, 1, 000, 2,500, 5, 000, and 10, 000 micrograms per milliliter of culture medium and the results were compared with those from control cultures. Incidence of chromosome breaks was higher in the experimental groups than in control. These effect was prominent in the concentration of 250 micrograms per milliliter or more. The numerical aberrations of the chromosomes were no remarkable difference, but -the higher concentrations of MSG were used, the more cells with aneuploidy were noted.
In the cultures 2,500 micrograms of MSG per milliliter added, remarkable retardation of the cell growth was noted, and in the group of 5, 000 micrograms of MSG or more per milliliter cells grew rarely.

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