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Prognostic value of preoperative lymphocyte-monocyte ratio in elderly patients with advanced epithelial ovarian cancer

대한산부인과학회지 2017년 60권 6호 p.558 ~ 564
권병수, 이현주, 양주석, 송용중, 서동수, 이동형, 김기형,
소속 상세정보
권병수 ( Kwon Byung-Su ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
이현주 ( Lee Hyun-Joo ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
양주석 ( Yang Ju-Seok ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
송용중 ( Song Yong-Jung ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
서동수 ( Suh Dong-Soo ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
이동형 ( Lee Dong-Hyung ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology
김기형 ( Kim Ki-Hyung ) - Pusan National University School of Medicine Department of Obstetrics and Gynecology

Abstract


Objective: To investigate the prognostic significance of preoperative lymphocyte-monocyte ratio (LMR) in elderly patients with advanced epithelial ovarian cancer (EOC) receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy.

Methods: A total of 42 elderly patients (≥65 years) diagnosed with EOC who are receiving primary cytoreductive surgery and adjuvant platinum-based chemotherapy from 2009 to 2012 was included. LMR was calculated from complete blood cell count sampled before operation. Receiver operating characteristic (ROC) curves were used to calculate optimal cut-off values for LMR. Prognostic significance with respect to overall survival (OS) and progression-free survival (PFS) were determined using log-rank test and Cox regression analysis.

Results: The optimized LMR cut-off value determined by ROC curve analysis was 3.63 for PFS and OS. The high LMR group (LMR ≥3.63) was found to be significantly more associated with optimal debulking (P=0.045) and platinum response (P=0.018) than the low LMR group. In addition, Kaplan-Meier analysis revealed the LMR-high group was significantly more associated with high PFS and OS rates (P=0.023 and P=0.033, respectively), and univariate analysis revealed that a high LMR, histology type, and optimal debulking and platinum responses were significantly associated with prolonged PFS and OS. However, subsequent Cox multivariate analysis showed only optimal debulking and platinum response were independent prognostic factors of PFS or OS.

Conclusion: This study suggests that LMR might be associated with treatment and survival outcomes in elderly patients with EOC receiving standard oncology treatment.

키워드

Aged; Ovarian epithelial cancer; Lymphocyte-monocyte ratio; Survival

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