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시상하부내로 투여한 Tetrodotoxin이 혈압 및 시상하부의 전기자극에 의한 승압반응에 미치는 영향 Effect of Intrahypothalamically Injected Tetrodotoxin on Pressor Responses to Electrical Stimulation in the Hypothalamus

대한생리학회지 1977년 11권 2호 p.23 ~ 31
김종식, 황현우, 김기순,
소속 상세정보
김종식 (  ) 
한양대학교 의과대학 생리학교실

황현우 (  ) 
한양대학교 의과대학 생리학교실
김기순 (  ) 
한양대학교 의과대학 생리학교실

Abstract


It is proposed in the present study to investigate the effects of TTX intravenously or intrahypothalamically administered on the arterial blood pressure and respiration and also to explore effect of intrahypothalamically administered TTX on the pressure responses to electrical stimulation in the hypothalamus. The results obtained are as follows;
1) The pressure responses to electrical stimulation in the hypothalamus were markedly reduced after administration of TTX.
In the 0.01, ?g/kg of TTX administered group, the pressor responses were almost abolished in 6 minutes and there was no tendency toward recovery throughout the experiment.
2) In 0.01 g/kg of TTX administered group, the mean arterial blood pressure and heart rate were -gradually reduced while there was a transient increase in respiratory rate followed by. slow recovery thereafter. On the other hand no changes in arterial blood pressure, heart rate and.respiration were observed in 0. 005 ?g/kg TTX administered group.
3) Following intravenous administration of l g/kg TTX, the arterial blood pressure and -heart rate were slowly reduced by 60 minutes while no marked changes were found in respiration.
From the results of present study it is strongly suggested that TTX exerts its depressant effect not-only on peripheral nerves but also on central nervous system.

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