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肝損傷에 依한 血淸 및 肝組織 Quinine Oxidase 活性의 消長에 關하여

Changes in Serum and Liver Quinine Oxidase Activity due to Liver Injury

대한생화학회잡지 1965년 2권 1호 p.17 ~ 23
이원영,
소속 상세정보
이원영 (  ) - 서울대학교 의과대학 생화학교실

Abstract


Rabbit was subjected to investigate the interrelationship between serum and liver quinine oxidase activity by experimental liver injury.
40 rabbits received partial ligation of liver and 40 partial hepatectomy at 1/3 portion of left liver lobe. 2, 5, 10, and 15 days after operation, 10 rabbits out of each group were sacrificed respectively and blood samples and remaining liver tissues were taken out for quinine oxidase assay.
Blood drawn before operation and resected liver tissue by hepatectomy were assayed for control experiment. Serum and liver quinine oxidase activities were deter-mined after Bays-Ballot & Terlingen S1) method using serum and supernate of 20 x liver homogenate. The results of this investigation are as follows.
1. The serum quinine oxidase activity of control rabbit is 0.4 unit/ml. The level of this enzyme in serum is almost unchanged until 5 days after operation, but on the 10th and 15th days increases significantly and remarkably (17. 8 unit/ml in hepatectomized group on the 15th day).
2. Liver quinine oxidase activity of control tissue is 2, 280 unit/gm. The level of this enzyme decreases until 5 days after operation.(1.480 unit/gm and 64.9% of control in hepatectomized group on the 2nd day), but on the 10th and 15th days increases significantly and
remarkably (4, 480 unit/gin, 196. 4% of control tissue in hepatectomized group on 15th day after operation).
From the data, thus obtained, the author concluded that the increase of serum enzyme was reflect of the compensatory increase of tissue enzyme of remaining liver rather than the result of leakage out of demaged liver tissue, and partial hepatectomy was more serious than partial ligation with respect to liver injury.

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