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Madecassol이 백서 간세포 괴사에 미치는 영향 Effect of Maudecassol to Hepatic Necrisis of Mice

대한성형외과학회지 1977년 4권 2호 p.11 ~ 21
이세일, 오상환, 유재덕,
소속 상세정보
이세일 (  ) 
연세대학교 의과대학 성형외과학교실

오상환 (  ) 
연세대학교 의과대학 성형외과학교실
유재덕 (  ) 
연세대학교 의과대학 성형외과학교실

Abstract


Titrated extract of centella asiatica(Madecassol) was reported to accelerate wound healing with minimal scarring. In vitro studies showed that madecassol suppressed fibroblastic proliferation. In an experimental study, reduction of portal tract fibrosis was noted in the livers of mice infestated with bilharziasis and Crated with madecassol.
The authors had an analysis of early effect of madecassol to hepatic necrosis -of mice prepared with thioacethamide.
The electonmicroscopic findings are increased glycogen, RER(Rough endoplasmic reticulum), SER(Smooth endoplasmic reticulum) and ribosome in the cytoplasm(Group of injection of madecassol). After madecassol therapy, the liver cell necrosis was minimal comparing to thioacetamide group.

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