Sodium Phenobarbitone 및 β- Diethylaminoethyl Diphenylpropyl Acetate (SKF 525 A) 가 Ngaione 에 중독된 흰쥐의 간장병변(肝臟病變)에 미치는 영향
Effect of Sodium Phenobarbitone and β- Diethylaminoethyl Diphenylpropyl Acetate ( SKF 525 A ) on the Liver Lesions Caused by a Single Intraperitoneal Dose of Ngaione in the Rat
이준섭,
소속 상세정보
이준섭 ( )
서울대학교 농과대학 수의학과
KMID : 0359319740140020215
Abstract
Ngaione isolated from leaves of Myoporum deserti was dosed to the phenbarbitone and SKF 525 A pretreated male rat and studied the liver lesions.
The results obtained were summarized as follows:
1. The liver lesions are mostly zonally distributed and involved the midzonal parenchyma chiefly with tendence to include also associated periportal hepatocytes.
2. The histopathology of liver due to ngaione after phenoharbitone pretreatment is characterized by the consistent pretence of degeneration and necrosis of the periportal parenchyma.
3. Zonal liver lesions caused by ngaione in the SKF 525 A pretreated rat are consistently periacinar in location.
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