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제주지역의 돼지 써코바이러스 2형 관련 장염에 대한 병리학적 특징

Pathological characteristics on porcine enteritis associated with porcine circovirus type 2 in Jeju

대한수의학회지 2020년 60권 3호 p.155 ~ 161
문성환, 양형석, 김재훈,
소속 상세정보
문성환 ( Mun Seong-Hwan ) - Jeju Self-Governing Provincial Veterinary Research Institute
양형석 ( Yang Hyoung-Seok ) - Jeju Self-Governing Provincial Veterinary Research Institute
김재훈 ( Kim Jae-Hoon ) - Jeju National University College of Veterinary Medicine

Abstract


From 2006 to 2009, 50 pigs suspected of enteritis associated with porcine circovirus type 2 (PCV-2) (EAPC) were collected. Gross and histopathologic examinations and immunohistochemistry (IHC) were performed on the small intestine of 50 pigs. The pigs with EAPC were concentrated in grower pigs (68%), and diarrhea (84%) was the most common clinical sign. Grossly, the walls of the small intestine were thickened, and mesenteric lymph nodes were enlarged. The histopathologic features in the small intestine with EAPC were characterized by lymphoid depletion, histiocytic infiltration, and formation of basophilic grape-like inclusion bodies and multinucleated giant cells in gut-associated lymphatic tissue (GALT) and lamina propria. According to IHC, PCV-2 antigens were more intense and distributed widely in GALT (98%) than lamina propria (82%) of the small intestine. Coinfection with other enteric pathogens was detected in 26 pigs (52%). Twenty-four pigs (48%) were confirmed to be a PCV-2 single infection. Collectively, infected PCV-2 in the small intestine may induce an immunosuppressive status of individuals and then allow secondary co-infections in the digestive system. This study shows that PCV-2 can induce diarrhea and enteric lesions in pigs without a co-infection of other enteric pathogens.

키워드

circovirus; enteritis; gut-associated lymphatic tissue; lymphoid depletion;swine

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