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Association between extract from fruit of Opuntia ficus-indica and streptozotocin-induced diabetic rats

대한수의학회지 2021년 61권 1호 p.6 ~ 6
Jo Hyun-Mu, 김현석, 김대중, 심성보,
소속 상세정보
 ( Jo Hyun-Mu ) - Catholic University Eunpyeong St. Mary’s Hospital Research Institute of Medical Science
김현석 ( Kim Hyun-Seok ) - Catholic University Bucheon St. Mary’s Hospital Department of Thoracic and Cardiovascular Surgery
김대중 ( Kim Dae-Joong ) - Chungbuk National University College of Veterinary Medicine
심성보 ( Sim Sung-Bo ) - Catholic University Bucheon St. Mary’s Hospital Department of Thoracic and Cardiovascular Surgery

Abstract


Opuntia ficus-indica has traditionally been used in prevention and treatment of various diseases such as diabetes mellitus. The current study was performed to determine whether Opuntia ficus-indica is associated with diabetes. Diabetic rat models were induced with streptozotocin (STZ). This study divided rats into 1 day (short-term) and 4 consecutive weeks (long-terms) of daily administration. These groups were subdivided into four groups each other for assessment of blood glucose level as follows: Group 1, untreated rats given distilled water; Group 2, untreated rats given Opuntia ficus-indica; Group 3, STZ-induced diabetic rats given distilled water; Group 4, STZ-induced diabetic rats given Opuntia ficus-indica. Blood glucose level was measured for one day and four weeks. In addition, serum markers of alanine aminotransferase (ALT), aspartate transaminase (AST), cholesterol, and creatinine were determined, and total protein triglycerides were measured at four weeks. Blood glucose level was highest in both groups (Group 3 and Group 4) at 30 minutes and two weeks and gradually decreased in a time-dependent manner. The difference in blood glucose among the four groups was significant (p < 0.05). Additionally, the levels of ALT, AST and triglycerides were significantly decreased by Opuntia ficus-indica.

키워드

Opuntia; diabetes mellitus; blood glucose; alanine transaminase; aspartate aminotransferases

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