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만성 콩팥병 환자에서 저용량 바클로펜 사용 후 발생한 비경련뇌전증지속상태

Low Doses of Baclofen Induced Nonconvulsive Status Epilepticus in a Patient with Chronic Kidney Disease

대한신경과학회지 2021년 39권 1호 p.26 ~ 39
김수현, 이영배, 김현지, 김형호, 윤지영, 이정화, 김건하,
소속 상세정보
김수현 ( Kim Soo-Hyun ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology
이영배 ( Lee Young-Bae ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology
김현지 ( Kim Hyun-Ji ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology
김형호 ( Kim Hyung-Ho ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology
윤지영 ( Yun Ji-Young ) - Ewha Womans University College of Medicine Ewha Womans University Seoul Hospital Department of Neurology
이정화 ( Lee Jung-Hwa ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology
김건하 ( Kim Geon-Ha ) - Ewha Womans University College of Medicine Ewha Womans University Mokdong Hospital Department of Neurology

Abstract


Baclofen, a gamma-aminobutyric acid B agonist, is frequently used in the treatment of various neurologic diseases including spasticity, dystonia and trigeminal neuralgia. This drug usually acts at the presynaptic motor neuron to induce an antispastic response. Oral baclofen toxicity is extremely rare, but is often reported to affect patients with renal disease. Here, we report a patient with chronic kidney disease who was treated with relatively low doses of baclofen (5 mg twice per day) and experienced nonconvulsive status epilepticus.

키워드

Status epilepticus; Baclofen; Chronic kidney disease

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