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各種抗炎劑가 葡萄膜炎때의 血管透過性에 미치는 影響

The effects of anti-inflammatory agents on blood-aqueous-barrier in experimental uveitis

대한안과학회지 1969년 10권 3호 p.19 ~ 23
朴成道, 申京煥, 李權鎬,
소속 상세정보
朴成道 (  ) - 首都 陸軍病院 眼科
申京煥 (  ) - 서울대학교 醫科大學 眼科學敎室
李權鎬 (  ) - 서울대학교 醫科大學 眼科學敎室

Abstract


The purpose of this paper is to study the effects of anti-inflammatory agents on the blood-aqueousbarrier in experimentally induced uveitis. 10% solution of sodium fluorescein was injected intrvenously in the ear vein of rabbits (0.25 ml/kg) and fluorescein curve was drawn after the method of Amsler and Huber.
Experimental uveitis was induced by the injection of 0. 2 ml of human serum into the vitreous body.
After uveitis had been induced, three kinds of anti-inflammatory agents-Prednisolone, Benzyron and Methotrexate were given orally.
In control animals in which no uveitis was induced, no changes in fluorescein curve were demonstrated .before and after the administrations of drugs.
In animals with uveitis, marked increases of the blood-aqueous barrier were noted. When Benoyron and Prednisolone were given to these animals, normalization of the fluorescein curves were demonstrated.
Methotrexate had no effects on--the-fluorescein curves in uveitis animals, showing no improvements in the permeability of uveal vessels. This ineffectiveness seemed to be due to the resistance of rabbits to methotrexate.

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