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蒼朮 Alkaloid가 Schedule Controlled Behavior에 미치는 影響

The Effect of Atractylis Alkaloid on Schedule -Controlled Behavior

대한약리학잡지 1968년 4권 1호 p.33 ~ 36
洪思岳, 文東淵,
소속 상세정보
洪思岳 (  ) - 서울대학교 醫科大學 藥理學敎室
文東淵 (  ) - 서울대학교 醫科大學 藥理學敎室

Abstract


The effect on schedule controlled behavior and toxicity of Atractylis alkaloid was investigated in the pigeons which were trained on a multiple fixed-ratio fixed-interval schedule of food presentation.
Atractylis alkaloid decreased the rate of responding during both the fixed-interval and fixed ratio component of the schedule at 10 mg/kg. Further depression occurred at 30 mg/kg. This “flat dose-response curve for depression of conditioned behavior was typical of tranquilizers.
Conclusively it was suspected that Atractylis alkaloid had major tranquilizing activity.

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