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Ephedrine 및 Epinephrine의 作用에 미치는 Pyrogallol의 影響

The Efffect of Pyrogallol on the Pharmacological Action of Ephedrine and Epinephrine

대한약리학잡지 1968년 4권 1호 p.41 ~ 44
임주택,
소속 상세정보
임주택 (  ) - 우석대학교 의과대학 약리학교실

Abstract


Pyrogallol is recently known to be a inhibitor of catechol-o-methyl transferase (COMT) and increase the action of epinephrine on the isolated rabbit atria. In this experiment, the author attempated to investigate the influence of pyrogallol on the effect of ephedrine and epinephrine on the blood pressure of the rabbit and isolated atria and excised intestine of the rabbit.
The results obtained were summarized as follows;
1. Pyrogallol tends to increase the blood pressure and respiration of the rabbit. But it has no significant effect on the excised rabbit atria and intestine.
2. The effect of ephedrine on the blood pressure and respiration, isolated atria and excised intestine of the rabbit were not influenced by the pretreatment with pyrogallol.
3. The effect of epinephrine on the blood pressure and isolated atria of the rabbit is potentiated with pyrogallol pretreatment.

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