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人蔘의 中樞神經系에 對한 作用

Effects of Panax Ginseng on the Central Nervous System

대한약리학잡지 1969년 5권 1호 p.23 ~ 28
吳鎭燮 (  ) - 서울대학교 醫科大學 藥理學敎室

文東淵 (  ) - 서울대학교 醫科大學 藥理學敎室
朴贊雄 (  ) - 서울대학교 醫科大學 藥理學敎室

Abstract


Saponin, essential oil and fat oil fractions were fractionated from Panax Ginseng and their potentiating or inhibiting actions during the combined use of several central nervous system stimulants or depressants were observed to elucidate the possible role of Ginseng fractions on the central nervous system.
Saponin, essential oil and fat oil fractions shortened nembutal sleeping time at low dosage (10 mg/kg) but contrarily they produced potentiation of nembutal hypnosis at high dosage (50mg/kg).
In the toxicity study of amphetamine, saponin and essential oil fractions reduced the toxicity in aggregated mice at high dosage (100 mg/kg) but such decreased lethality was not observed in isolated mice.
Ginseng fractions, especially high dose of saponin fraction (100mg/kg) prolonged the survival time after injection of convulsive dose of metrazol or cocaine and saponin fraction also prolonged the onset of cocaine convulsion at high dosage (100 mg/kg).

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