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우리나라 백부자(Aconitum Koreanum R. Raymond)의 적출 개구리 심장 운동에 대한 작용 및 LD_(50)

The Action of Extracts of Aconitum Koreanum R. Raymond on isolated Frog heart and LD_(50)

대한약리학잡지 1969년 5권 2호 p.1 ~ 5
朴靜純, 金潤根,
소속 상세정보
朴靜純 (  ) - 가톨릭 醫科大學 藥理學敎室
金潤根 (  ) - 가톨릭 醫科大學 藥理學敎室

Abstract


Aconitum Koreanum rhizoma has been applied in therapy from old in oriental medicine (Korean Hanbang), The action of the water and alcohol extracts of the rhizoma and root of Aconitum Koreanum R. Raymond, a common herb in Korea, on the isolated Frog heart and LD_(50) were observed.
The results of the studies were as follows:
1. The cardiac effect in the concentration of the extracts(10^(-3)) was increased and duratrin of action prolonged approximately 10 minutes, but in the extracts (3×10^(-3))blocked.
2. The LD_(50) of extracts were 722 mg/kg (water) and 151mg/kg (alcohol) intraperitoneally in mice.

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