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Alloxan 投與家兎의 代謝에 미치는 Reserpine의 效果

The Effect of Reserpine on the Metabolism of the Alloxan treated Rabbit

대한약리학잡지 1969년 5권 2호 p.7 ~ 12
신경철,
소속 상세정보
신경철 (  ) - 우석대학교 의과대학 약리학교실

Abstract


Alloxan is a diabetogenic agent which destroys the beta-cell of the Langerhan´s islet of pancreas and it disturbs the secretion of insulin. It is known that alloxan interfers with the hepatic enzyme activity and some aspect of the other metabolism.
The author attempted to investigate the influence of reserpine upon the serum transaminase activity, blood sugar and serum total cholesterol contents of rabbit treated alloxan.
The results obtained were summarized as follows;
1. The serum GOT and GPT activity of alloxanized rabbit pretreated with reserpine showed marked decrease compared with alloxan control group.
2. The blood sugar level of alloxanized rabbit pretreated with reserpine showed lower than the alloxan control group.
3. The total cholesterol level of alloxanized rabbit pretreated with reserpine was lower than that of alloxan control group.

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