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토끼 담낭절펼에 대한 Caerulein의 작용 Effect of Caerulein on the Isolated Gall Bladder Strips of Rabbits

대한약리학잡지 1974년 10권 1호 p.47 ~ 54
趙台淳, 李宇柱, 洪思奭,
소속 상세정보
趙台淳 (  ) 
延世大學校 醫科大學 藥理學敎室

李宇柱 (  ) 
延世大學校 醫科大學 藥理學敎室
洪思奭 (  ) 
延世大學校 醫科大學 藥理學敎室

Abstract


The isolated rabbit gall bladder strips were prepared according to the technique described by Amer and Becvar (1969). The strips were placed in a bath containing 100 ml of Locke-Ringer solution maintained at 38℃. Oxygen was continuously bubbled through the solution. The tension of the muscle strip was initially adjusted to 0.7 g. The contractile response was measured isometrically by a force-displacement transducer connected to a polygraph.
The effect of a number of autonomic drugs were studied for their interaction with caerulein (Prof. V Erspamer, F.I. 6934 Caerulein, Farmitalia, Italia), a gastrin or CCK.PZ like peptide, on isolated rabbit gall bladder strips.
In this preparation caerulein produced contractions of CCK-PZ type, but the relative potency on a weight basis was 40 times that of CCK-PZ. The response of caerulein was not modified by either cholinergic or alpha or beta adrenergic blockade. However, the response of caerulein and of barium on the strips were prevented by papaverine or aminophylline. Isoproterenol, papaverine or aminophylline alone relaxed the preparation whereas caerulein, CCK-PZ, acetylcholine, serotonin, histamine or barium chloride contracted the preparation.
In summary, it is concluded that caerulein on the gall bladder strip seems to act independently of the autonomic nervous system and mediated via mechanisms apparently similar to those involved in the action of barium chloride.

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