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흰쥐의 胃酸분비에 대한 高張포도당용액의 영향 Effects of hypertonic glucose solution on acid secration of rat stomach

대한약리학잡지 1976년 12권 1호 p.57 ~ 62
金惠英, 趙台淳, 洪思奭,
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金惠英 (  ) 
延世大學校 醫科大學 藥理學敎室

趙台淳 (  ) 
延世大學校 醫科大學 藥理學敎室
洪思奭 (  ) 
延世大學校 醫科大學 藥理學敎室

Abstract


Using modified technique of Schmidt et al, as described previous (Korean J. Pharmacol 9 : 17, 1973), the stomach of female rats were perfused with physiological saline under urethane anesthesia. The acid-secretory response of the perfused stomach to i.v. hypertonic glucose (50%), casein hydrolysate (20%) or saline (6%) solution were studied with or without histamine or methacholine stimulation.
A significant decrease of acid secretion from the rat stomach was induced by i.v. hypertonic glucose or saline solution. The histamine-stimulated acid secretion was also decreased by simultaneous administration of the hypertonic glucose or saline. However, methacholine-stimulated acid response was not affected by the hypertonic glucose. Intravenous infusion of 20% casein hydrolysate solution resulted in an increase in acid output from the stomach under histamine stimuli.
These results lead to the conclusion that the inhibitory responses of acid secretion due to i.v. hypertonic glucose solution are brought through the effect of histaminergic, not cholnergic mechanism(s) in the gastric secretion.

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