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인삼이 흰쥐의 조건회피반응 습득에 미치는 영향 Effect of Ginseng on the acquisition ofconditioned avoidance response in rats

대한약리학잡지 1976년 12권 1호 p.63 ~ 67
홍사악, 장현갑, 박찬웅,
소속 상세정보
홍사악 (  ) 
서울대학교 의과대학 약리학교실

장현갑 (  ) 
서울대학교 사회과학대학 심리학과
박찬웅 (  ) 
서울대학교 의과대학 약리학교실

Abstract


The purpose of the present study was to see the Panax Ginseng has any influence upon the acquisition of the conditioned avoidance response(CAR) in rats.
Sixty male rats of Holtzman strain were used. The animal weighed between 20 and 300 gm at the beginning of the experiment. Training of avoidance conditioning was done in a two-way shuttle box which was separated into two compartments by a guilotine door. The conditioned stimulus (CS) was a light beam and the unconditioned stimulus (UCS) was an electric shock. The shock was presented 10 sec. after onset of the CS and continued until the subject crossed to the opposite safety compartment within 20 sec. after onset of UCS. Each S was received 30 trials a day (one session) for 6 consecutive sessions. The number of CR which avoided successfuly without having shock and the number of fecal balls during the conditioning were served as an index of learning performance and emotionality.
The results obtained as follows.
All doses of Ginseng saponin treated animals showed more CR than control, but did not differ significantly from control.
Ginseng saponin treated animals with the doses of 50~100 mg/kg defecated the fecal balls significantly less frequent than the placebo control during CAR.

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